The history of Uganda Air Cargo dates back to the late 1940s, when the country was still a British colony. The first major airline operating in the area was Uganda Airlines, which was founded in 1947 and operated domestic services within the country. In the early 1970s, the airline began to expand its operations and began offering international services. In 1976, it was rebranded as Uganda Air Cargo and began offering air cargo services to neighboring countries, including Kenya, Tanzania, and Rwanda.

The airline's first fleet consisted of a small number of Douglas DC-7 aircraft, which were used for cargo transport. Over time, the airline expanded its fleet to include a variety of other aircraft, including the Boeing 707 and McDonnell Douglas DC-10. The airline also operated a number of smaller aircraft, such as the Beechcraft Super King Air, for regional cargo services. In the early 1990s, the airline began to modernize its fleet with the introduction of the Airbus A300-600 freighter, which provided the airline with greater lifting capacity and range.

Uganda Air Cargo has had a number of important milestones over the years. One of the most significant was the launch of its first international flight in 1978, which flew to Nairobi, Kenya. This marked the airline's first foray into international markets and opened up new opportunities for the airline. In 1985, the airline launched its first inter-African route, connecting Entebbe, Uganda to Dar es Salaam, Tanzania. This route opened up trade and transport links between the two countries, which had been isolated for many years.

In the 1980s, Uganda Air Cargo was one of the first airlines in the region to introduce a frequent flyer program, which allowed customers to accumulate points to redeem for free flights or other rewards. In the early 2000s, the airline began to offer passenger services in addition to its cargo services, and was the first Ugandan airline to offer a loyalty program for its passengers.

Unfortunately, Uganda Air Cargo has been involved in a number of incidents over the years. In 1994, one of its aircraft crashed in Kenya, killing all five people onboard. In 2000, the airline was the subject of a federal investigation into alleged corruption and mismanagement. The investigation led to the suspension of the airline's license and the closure of its operations.

Despite its troubled past, Uganda Air Cargo continues to play an important role in the region's aviation industry. The airline has continued to modernize its fleet, and today operates a variety of Airbus and Boeing aircraft, as well as smaller turboprop aircraft for regional operations. It continues to offer a variety of services, including cargo and passenger services, as well as loyalty programs and other services. The airline is committed to providing safe and reliable air transportation to customers in Uganda and throughout the region.